@wicked solar Apologies for the direct tag, probably worth knowing about. We (myself and the EnderIO devs) think we know what's causing this, and it's kinda likely to be an issue for other players depending on how they set up their base.
The TL;DR - if you use EnderIO and run a long line of conduits, the world cannot be loaded and will crash. This isn't strictly a single long line, but more the scenario I'm in which is that a line of energy conduits is being run from my power source and sort of branches out around the base, about 600 conduits in total. This is on a server with 8GB memory, somewhere around ~500 conduits is where the issue is likely to appear. It won't be an instant crash when you go above the limit, but it will fail to load when you quit out and try and reload - only hit it on MP but 95% confident singleplayer would be the exact same.
This isn't something that can be fixed client side or via config, it needs an update to the mod from the EnderIO team. But definitely more of an issue for server players because if the server is up 24/7, world backups will hit the same issue as well and you are then fully stuck waiting on the mod fix once the unaffected server backups are deleted.
(Sorry for finding more EnderIO issues, the modern rework is cursed
)