Sorry, You'll have to remind me what the issue is. It looks like I was suggesting turning off plugins and buffer size adjustments. so probably crackles and pops?
crackles and pops are usually buffer errors, so if your CPU is not keeping up with the audio processing in real time, or in some cases plugins can cause this either by misbehaving (like the infamous Nvidia noise reduction) or if maybe a gate or something is causing a harsh cut in and out.
Making sure your samples rate and bit depth are matched for all devices in the system can help. And especially making sure you're using 48khz sample rate, and not higher than that.
(higher sample rates are much more stressful on the system and give no benefit to sound quality, contrary to popular belief and marketing claims)
If you try those things and still have issues, you might be due for driver updates. Make sure all your system hardware drivers are up to date, check motherboard chipset drivers, and even BIOS. Some usb chipsets have been known to have issues with audio devices so... there's a chance that could cause it.
Also general system gunk.... maybe you are due for a wipe and reinstall of the OS? I wouldn't tell anybody they have to do that, or that it will for sure clear up problems... but I don't know how you manage your computer and some people get benefit from wiping the drive and starting over if it has been a year or two since they last did so.
But I would do the driver and BIOS stuff, and settings checks first.