https://www.curseforge.com/minecraft/mc-mods/extreme-reactors
Currently uranium from IE has only 1 real use, as a passive heat source for Pneumaticraft or as a passive heat source for the Thermoeletric generator.
One thing that could make Uranium more useful, and turn it into an end game power source, is the addition of something like Extreme Reactors. Adding the mod would not affect currently existing worlds, as you can configure it to use Uranium as a direct replacement for Yellorium, and you can (and honestly should) disable Yellorium world gen as it would redundant.
I have already done an initial test for compatibility with IV 1.6 and so far there does not seem to be any issues. Recipes would need to be adjusted to be brought in line with the other recipes in the game. This could give us a use for lead in the game also, as currently it is only used in the creation of a very limited number of items. Lead could be used instead of Graphite for some recipes (like basic vs reinforced).

