#fatigue and wrong mouse shape
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plus strength and conditioning training for your whole body
nutrition and hydration
proper posture
you can only know if it's the shape fault by trying different shapes
also, the way you're playing is also a big thing. if you use extreme tension to aim and spray, its quite common to have your hand hurt after some time, regardless of shape. Altough of course, the shape may determine as well how fast it takes for your hands to fatique
that's so me right now