This is a weird and minor one, but i've noticed it on all 3 of the Labyrinth doors i've had to unlock from one specific side so far.
The pulse rifle is unable to destroy the cubes to open them which is bizarre. This is obviously very minor but was easy to reproduce. I had to swap to my Rupture Cannon to open it because i could not use the Pulse Rifle no matter how many different angles i tried.
This is on Hardcore that i noticed it, though i doubt that's any cause for the bug