Creatinine clearance

[small jolt]

creatinine clearance, like, how clear the chemicals would form in the bladder?

[surreal heath]

Just did my end of year exams and have already forgotten how to calculate this

[cosmic kayak]

What about the patients weight, hight and maybe even diuresis?

[small jolt]

his medical conditions count, too

[cosmic kayak]

Yes!

[small jolt]

yeah

[cosmic kayak]

Age could help

[small jolt]

age is not that effective though, it's only the body's reaction to hormonal changes and time passing
yet, it's not what it is called "age"

[cosmic kayak]

Also we need the values of urea and creatinine in serum too

[surreal heath]

creatinine clearance = (((140 - age in years) x (wt in kg)) x 1.23) / (serum creatinine in micromol/l). That was the equation in my lectures, not much good here

[cosmic kayak]

Well you do have a point but also a 10 month old, a 20 year old (who might take creatinine supplements) and a 70 year old (which probably has EGF of below 60) could help us solve this

[small jolt]

correct

agreeable

[cosmic kayak]

Nice one. We use it too

They did mention plasma concentration of creatinine. Although I'm not too sure of the variation between levels of creatinine in plasma and serum

[surreal heath]

Yes I was wondering if there was some equation to convert or if they are equivalent

[cosmic kayak]

Also you should multiply by 0.85 if the patient is a female

Could @stiff oriole possibly give us additional information or a hint?

[surreal heath]

Good to know thanks

[elfin cave]

wait omw to scour some weird formula 😔

[stiff oriole]

You don't need any additional info

[elfin cave]

bit sus that these 3 came up lemme find something with plasma thingy in it

https://qxmd.com/calculate/calculator_52/crcl-from-24h-urine#

sauce^

[elfin cave]

||111ml min?|| spoiler?

[cosmic kayak]

||111.11mL/min||

[elfin cave]

got a clue from this

spoilering it

[cosmic kayak]

I forgot how to mark it as a spoiler

Darn it

[elfin cave]

just edit it and go ||text||

[cosmic kayak]

Thanks for the help @elfin cave

[elfin cave]

np

[cosmic kayak]

No idea. I just embarrassed myself

[elfin cave]

double ||

just copy paste from mine 😭 👍

[cosmic kayak]

A-HA!
Gotcha. Thanks. Haven't used discord in ages tbh. So I forgot some of the stuff

[elfin cave]

also based for cowboy bepop pfp

[surreal heath]

Got the same btw

[elfin cave]

@stiff oriole i gotta thank you for increasing my internet digging skills with all the biology QOTWs 😭 (i'm sam, btw idk if you remember me 💀 )

[cosmic kayak]

Will we get a pat on the back if we were right?

[surreal heath]

I have the equation but don't know how to mark as spoiler

[elfin cave]

||text||

[cosmic kayak]

||

Text and then ||

[surreal heath]

Ty

[elfin cave]

isn't that really big of a number though?

[cosmic kayak]

Hey thats what the site said hahaha

[elfin cave]

i found the eq and got ||111.11||

idk which one's right

[surreal heath]

||(Urine creatinine concentration X Urine Flow Rate) / Plasma Creatinine Concentration ||

[cosmic kayak]

@elfin cave wait

[elfin cave]

hmm?

[surreal heath]

Yeah I meant to say I got the same as you @elfin cave

Sry

[cosmic kayak]

Bro... I'm too brainwashed from work to realise what I did

[elfin cave]

😭 yeah

i was tryna see where i went wrong

[surreal heath]

😅

[cosmic kayak]

Nah you did great. I just probably messed up with switching the literes to mL

Woops

[elfin cave]

i was like dang maybe paper calculation doesn't work

also tbf i didn't put the ||0.11||

this is the first QOTW i've gotten right first try 😭 meanwhile i've gone rat limb stats scavenging in the past

[cosmic kayak]

Tbh I'm so used to the data we use everyday in our lab when we do clearances that it took my brain a bit to process the info

Hopefully there will be more medical things like this. I like it

[elfin cave]

i just googled creatinine clearance and put all the data we have and landed on the initial link i sent

then i dug more and found the eq i could use manually

[elfin cave]

this was my first clue on what was relevant

[surreal heath]

Yeah I've enjoyed lurking on the past medical ones, this has been the first that's landed durring a time that I'm free

[cosmic kayak]

I sometimes have the stoopid when it comes to maths haha. My coworker today wrote that 0 > 0.1

[elfin cave]

then i googled further with those 3 and ended up on some research link

[cosmic kayak]

Smart cookie

[elfin cave]

i have to give robin full credit though 😭 i have bookmarked like 30 links from his other QOTWs

[cosmic kayak]

Are you in the medical field or do you just surf the Internet for info

[elfin cave]

i like larping as a med appreciator but i just graduated highschool 💀

[cosmic kayak]

Smol bean

[elfin cave]

so like i do have enough to know what all the stats mean but i've never had to use them

[surreal heath]

Damn, seems you've already got the research down anyway

[elfin cave]

😭

i should be touching grass

[cosmic kayak]

If you're interested in seeing human serums lmk

[surreal heath]

I'm year 1 med so haven't got much more idea about it really

[elfin cave]

again i used to be some sorta "waouw i wanna be a cardiothoracic surgeon 🤓 " (yes i was dumb)

[cosmic kayak]

💀

[elfin cave]

omg sure

it's like 2AM thou i'll be back in a few hours with a better working brain

[surreal heath]

I have a few mates who want that job, there's only one job opening for that in my country tho

[cosmic kayak]

And I shall be asleep. It's almost 11pm for me. Do hmu when you're down for an educational chat or something of the sorts

[elfin cave]

i did like the idea of performing CABG idk "wow i get to stop the heart? 🤓 " kinda stuff

[cosmic kayak]

Luckily not many people need that kind of doc

[surreal heath]

Very true, what role are you in if you don't mind me asking?

[elfin cave]

@golden mango nigul you might like this QOTW you med larper

[cosmic kayak]

I'm sadly not a doctor. Though thanks to my educational program I'm a nurse a midwife and a laboratory technician as we would call it (but to be honest I'm working as a aliexpress biochemist and a technician since I run the lab (kinda))

It's weird when I explain it in English but I swear it makes sense

[surreal heath]

Forget about 'sadly' not a doctor. Sounds like you do more than most doctors I know

[elfin cave]

lab technicians are goated though

[cosmic kayak]

🥹

[surreal heath]

Exactly

[cosmic kayak]

I'm lucky to work in a polyclinic which has various specialists and a lab and when I work alone (without our biochemist/director) I'm next in line of responsibility so I get to do my own thing and also learn a lot of stuff from doctors

Though the downside is that we don't really have any emergencies so surgically speaking I'm not the most informed

[elfin cave]

that sounds fun ngl 😔 if the salary wasn't terrible and super competitive i'd have considered this field

[cosmic kayak]

I mean I'm happy

[elfin cave]

salary being terrible is exclusive to my country idk

[cosmic kayak]

Ah

You're not the only one trust me. Mine was not the best until I was ready to quit

[surreal heath]

Sounds really interesting, I'm doing a research project this summer (if it gets funded 🤞) and I'm really looking forward to working in a lab environment.

[cosmic kayak]

It's hella fun. And working with some of the newest machines is unreal

[elfin cave]

idk i suddenly realised the importance of a corporate insured job when my mom was in the ICU 😭 so i'll probably be going the corporate rat route

[past nymph]

pee

[elfin cave]

piss

🙏

[cosmic kayak]

Tho tbh I'm assuming your lab work and mine won't be the same

[surreal heath]

Well considering the doctors in my country are on strike atm I don't think I could recommend med, for the money anyway

[elfin cave]

i'd never go to med for money ngl, that's very passion and energy driven

[surreal heath]

Mine would be mostly on lung cells and fibrosis

[elfin cave]

i met so many cool doctors, but all of them were overworked to death

[surreal heath]

Something for me to look forward to ig

[elfin cave]

😭 the non-ICU emergency room ones were a bit chiller

[surreal heath]

What area are you involved in?

[surreal heath]

Was aiming for ED or GP so probably not going to be the chillist of people lol

[elfin cave]

the ER was such a horrifying place ngl, all stroke patients and screaming and crying overall yeah idk how they do it

it was night time so yeah mostly stroke patients

[cosmic kayak]

Try to get the best thing your country has to offer until you find something better elsewhere.

[elfin cave]

thas the plan

[cosmic kayak]

Rn the polyclinic is trying to stay on the path of internal medicine but we have a radiologist, oncologist- urologist, nephrologist.... on a daily basis. Other doctors don't work daily but some are; cardiologists, endocrinologist etc... a lot of specialist and I make most of the lab analyses happen

It's not the easiest thing to explain my job nor the posision I'm in since the type of schooling I went through is specific for my country and also the type of work I do is not an everyday thing

[cosmic kayak]

You get used to it. Went from labour and delivery to internal medicine ICU and dialysis department

the screaming isn't as loud as the time passes

[surreal heath]

A real jack of all trades then

[elfin cave]

ICU nurses are very efficient i feel kinda bad that i couldn't give them thank you notes like i did for the doc

[cosmic kayak]

It's never boring, I'll tell you that much

[surreal heath]

I could imagine

[cosmic kayak]

Oo also we got a pediatrician

[elfin cave]

that's a little terrifying 😭

[cosmic kayak]

Poor kiddo burnt his leg by spilling boiling water on himself... you can imagine how that went

[elfin cave]

so there's always screaming?

[surreal heath]

The full age range too then, you really do have it all

[surreal heath]

Yeah one of our first lectures was by a pediatrician... he brought pictures

[cosmic kayak]

In the ICU theres a few rules (and also anywhere with normal people): no screaming, no running for coworkers

The patients groan, cry, scream... hey imagine drawing blood from a 2 year old

[elfin cave]

oh i mean ER not ICU tbf i didn't hear much screams from the ICU just 20 beeping machines 👍

[cosmic kayak]

Almost. Plan is to expand even more

[cosmic kayak]

I mean yeah, thats the difference from the ER and ICU

[elfin cave]

i will be asking you for the serum thingy though seems cool

[surreal heath]

Thought you would have geriatric covered by all the dialysis

[cosmic kayak]

Idk where I could send them

[elfin cave]

ER was all screams

[elfin cave]

#science-and-engineering i think

[cosmic kayak]

Some of my experience is from working in the hospital. ICU, labour and delivery and dialysis is some of those. The rest is from the private polyclinic I work at rn

[surreal heath]

Ah, i see

[split escarp]

@stiff oriole indeed a med school moment. Thought you were in a neuroscience lab though

[golden mango]

what is the qotw

[golden mango]

aight imma do this after chicken nugget break

[elfin cave]

omg chicken nuggies 😔

[trail kite]

can i just point it out that the plasma creatinine is awfully low

[stiff oriole]

I'm multidisciplinary like that 🫡

[lusty acorn]

isn't the result simply ||111|| ml/min ?

[stiff oriole]

ANSWER

|| The formula is:
creatinine clearance = urine flow rate * urine conc of creatinine / plasma conc of creatinine

So that's 0.8*1.25/0.009= 111.11 ||

[still cradle]

i'm gonna take a wild guess and multiply two random numbers and hope. 1.25*.8=1 ( i don't know how to do this).