I upgraded from an RX570 that worked great to a ASRock AMD Radeon RX 6650 XT Challenger D Overclocked Dual Fan 8GB that has been horrible. If my monitors go to sleep then the screen does not come back up. Every time!. I have uninstalled and used DDU in safe mode and no fix.
MSI MEG B550 Unify Ryzen 5800X Latest BIOS and AMD drivers
This has been going on for months