mods such as "no crew requirements" or any mod that changes how many crew a building needs to operate can cause the save to crash repeatedly after the mod has been removed/ installed, as far as i can tell, this is due to the game being unhappy with "crew being assigned to somewhere they should not be" or something like that. the game just, doesn't handle incorrect crew assignments gracefully. they should just "go back to being idle as a fail state" before being reassigned to the correct place
i have uploaded
crash logs from a game without any mods installed to prove that "no mod that is currently active is causing the crash"
my creative save which is broken when loaded without any mods installed (i have experiences cases where i have loaded a normal save with a crew adjustment mod, and caused the same crash, it can happen backwards as well)
the mod that broke the save to begin with, with the mod active the save will load just fine.
(this mod is the one i am working on, but you can cause the same crash with the normal no crew required mod as well)
please keep in mind that this crash is not guaranteed to happen when adding or removing the mod for any save,it depends on "where the crew are assigned to or are being assigned to" the save i have provided should guarantee a crash
if you as a developer want to ever change the number of crew required per building in the future. or allow the player to adjust the value mid game. it could cause thousands of broken saves/ annoying to recover save files
hopefully i covered just about everything but if you need more info please let me know!