The Arrows fashioned from the meteorite will catalyze and awaken the Stand of any living creature they pierce, given that the target has sufficient spiritual strength. If the target lacks sufficient spiritual strength, contact with the Arrow will prove fatal; on the other hand, the Arrows normally only seek out and pierce those who will live.
In certain cases, such as with Ken Oyanagi and Tama, the wound caused by the Arrow will heal and leave a hole about the size of an average coin.
EFFECTS ON BLOODLINES
The Arrow's effects transfer through bloodlines, generally without exception. The Arrow that pierced DIO (and thus Jonathan Joestar's body) awakened Stands in the rest of the Joestar family. Members of a bloodline without the necessary spiritual strength to wield a Stand slowly die from its power, as if they were suffering a severe fever; such is the case with Holy Kujo and a young Josuke Higashikata. If the person responsible for the Arrow's influence dies, any family members suffering in this way are cured instantly, though Josuke fully awakened and retained his own Stand.
The Arrow can also awaken a Stand within one's siblings, as the wound from the Arrow that pierced Enrico Pucci also transferred to his brother Wes Bluemarine, granting him Weather Report.
If a person affected by the Arrow in this manner has a child after the source of the Arrow's effect dies, the child does not inherit a Stand of their own. The only known example of this scenario is Jolyne Cujoh, who didn't awaken her Stand until she cut herself on a shard of an Arrow.
A degree of uncertainty surrounds the effects of an Arrow piercing a Stand or its user after its awakening. When an Arrow pierces a Stand user, the user in question awakens a new ability; such is the case with Yoshikage Kira's Bites the Dust ability. However, this fact seems to be context-sensitive, as Giorno Giovanna's repeated contact with the Arrow in Black Sabbath's mouth seemingly has no effect beyond wounding him.