Making the end-game harder was an excellent call, but as a player, seeing my mighty weapons/armor turn into soggy cardboard versions of themselves is hard.
I know that's not really what's happening, but its what it feels like.
So, the main suggestion is to change the end-game in such a way where it doesn't feel like the player is losing power, but that the challenge is harder.
I have two suggestions as possible solutions to this problem:
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Enemy Sprites change on the trip up into a twisted demonic form and their description gets a small addendum explaining that the amulet is twisting them or something.
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Enemies combine: I have a lot of thoughts on how to make this work, but the TL;DR is to make a new enemy thats a mish-mash of existing enemies:
For the sewers an enemy with the evasion of a snake, multiplication of a fly swarm, speed of a crab.
For the Prison: a thieving, skeletal guard that grapples you to themselves, or one that summons a copy of itselve with the same powers.
For the mines: speed of the bat, magic of a shaman, rage of a brute, webs/poison of a cave spider.
EDIT: formatting to clarify what the main suggestion of the post is
