large bot, multiple servers, powerful storage tool, none of this is particularly useful
first of all, your first choice should be a relational database (sqlite, mysql, postresql, mariadb, etc) vs document database (mongodb being the main one)
relational databases are useful when you have a lot of relations, as in entries that are related to others in complex ways. for example, a discord message might be related to a channel, a guild, a guild member, then that guild member is related to a user, who is related to other users as friends etc
document databases are more similar to a file system, but i dont have any experience with them so i wont try to explain them any further, you absolutely should google relational vs document database if you arent familiar with this
if youve chosen a relational db, things like sequelize, prisma, etc are what are known as ORMs - Object Relational Mappers. You can absolutely use a relational database directly if you learn SQL (not too hard but there are a handful of footguns), but ORMs are designed to give you a more language specific, often type-safe API for your database. These can have some performance impact, but none of them is inherently best