pedigree analysis

[vale narwhal]

i am getting autosomal dominant, but the key says x linked reccesivees

[vestal dirge]

<@&1227988434510024734>

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[rugged grove]

,rotate

[rugged grove]

affected female with unaffected father isnt possible in x linked recessive

an ans key error perhaps

[vale narwhal]

arihant...

[pale zodiac]

I'll try this ruko

Actually kayi baar multiple types match kar rahe hote hain

And we have to choose the most probable

[rugged grove]

yeah.. like jabhi x linked hai it can be opened by autosomal too

[pale zodiac]

Hmm hmm

You gotta use some factors to rule the other out

Mai ek kaam kar raha tha bas kuch

Will se ek min me

[vale narwhal]

hnn

that i did

y linked to hoga nhi

[rugged grove]

yes thats male to male inheritance

holandric genes

[vale narwhal]

x linked me dominant agar hota to puri progeny hoti (if mother is hetero)

lekin agar vo hota to phir daughter ki next gen me nhi jata

[rugged grove]

i feel like it can be x linked dominant

x' here is affected

[vale narwhal]

progeny ke chnces ke hisab se socho

aise to maine bhi first me yahi socha tha

[rugged grove]

na that doesn't matter

probability ek large sampling size me dekhte hai

[vale narwhal]

bhyi matar nhi human hai 💀

[rugged grove]

but still

just cuz the probability of having a female child is 1/2 doesnt mean u have to always have one boy and one girl

likewise

[vale narwhal]

ik

par dekho 3 male hai 2 affected hai

2 daughter hai

dono affected hai

[rugged grove]

in general when we get asked qs like this in our tests, we usually have multiple correct options

cuz x linked can also be possible.. probability toh matlab population ki baat hai

[vale narwhal]

hnn

that ik

[rugged grove]

but yeah we can say that autosomal dominant may be the more appropriate opt

[vale narwhal]

thats what i am saying

[rugged grove]

yeah sry

that makes sense

all im saying tho is that we dont really look at probability to rule em out

may help with precision

[vale narwhal]

i mean hame bole hai sir ki best probable

😭

im not disregaring just

yaar best to vahi hona haina

[rugged grove]

yeah

that's right

[pale zodiac]

Okay

Now I’m here

Hey what does which colour represent @vale narwhal

Maine black and white me hi kiya hai ye

[vale narwhal]

pink is affected

blue isnt affected

vaise given nhi hai

par red ke hisab se hota hai

to that i am assuming

[pale zodiac]

Kahin usi ki vajah se na dikkat ho

[vale narwhal]

yeah that thing just came to my mind...

par still x linked nhi hota to ..

[pale zodiac]

I notice a pattern

Females are more affected than males

[vale narwhal]

hnn

they are

[pale zodiac]

That points towards X linked I suppose

[vale narwhal]

F1 me bhi and f2 me bhi

[pale zodiac]

Dominant nahi hai btw autosomal

[vale narwhal]

not so sure about this

[pale zodiac]

Tumhara kaise aaya I didn’t get it

[vale narwhal]

kyu?

[rugged grove]

exactly... cuz x linked he toh males have more chance of being affected.. esp if it's recessive

[vale narwhal]

hn

kyunki male me just would need one altered x

[pale zodiac]

Autosomal dominant agar hua to parentals me pure lines honge
Fir F1 would be affected completely

Which is not the case

[vale narwhal]

balki female me agar reccesive hai to 2

[vale narwhal]

pure line?

[pale zodiac]

AA aa

[vale narwhal]

hn vo mai smj gyi

[pale zodiac]

Gives all Aa

[rugged grove]

why pure lines, could be heterozygous

[vale narwhal]

dominant hetero bhi hota hai

...

[pale zodiac]

Accha haan

Sorry

[sonic elk]

I think so it can also be done by the statement that mitochondria is the power house of the cell

[vale narwhal]

Aa bhi ho sakti haina mother

[pale zodiac]

Hmm hmm

[vale narwhal]

dekho mai bhaga dungi
meri thread na khrb karo 😭

[pale zodiac]

Autosomal recessive bhi baith gaya mera to

[sonic elk]

I am telling till my extent of bio knowledge I will leave

My bad

[vale narwhal]

dikhao

[rapid crater]

stay on topic please.

[vale narwhal]

bhyi....

ik baat bato

ki agar meri cross kar rhi hai to there is 50% chnce na

mai kaise assume karlu ki dono me vahi hona

[pale zodiac]

Independent events hain ji

[rugged grove]

yup.. basically autosomal and x linked dominant as well as autosomal rec works here..

[vale narwhal]

ofc

[vale narwhal]

par still im talking about chance

[pale zodiac]

To ye bhi possibility to hai na

[pale zodiac]

Statistically socho

[vale narwhal]

most probs to nhi hona

[pale zodiac]

Hamara sample size chhota hai bohot

[vale narwhal]

vahi to mai bolri

[pale zodiac]

To iske bhi acche khaase chances hain

Idk upar ka lol

[pale zodiac]

Are but hamara sample size chhota hai na

Ab agar 6 times coin toss kiya agar

To jaruri thodi hai 3 times heads aayega

Hmm hmm

So now

I feel like ‘cause females are affected more

I’m tending towards X linked

[vale narwhal]

i dont think so

ki agar female more hai to x ke chance honge jyda

[pale zodiac]

Usme bhi issue hai I get it

[vale narwhal]

aree ik that
par ye assume ideal situations
ki hamare jo bhi punnet se aara vahi hona

[pale zodiac]

Naah aise nahi hota ji

Pedigree me le sakte hain baaki possibilities

[vale narwhal]

waah kaise nhi hota
humko bataye hai

ki best ans ke liye assume ideal

[vale narwhal]

le sakte hai

that i agree par to check hume dekhna pehle ideal hota hai

[pale zodiac]

Maybe idk then
Mai koi accha reason soch raha hun

To rule out others

Kyunki satisfy to saare ho jayenge I guess

X linked dominant ho raha hai satisfy kya?

[vale narwhal]

na

[pale zodiac]

Then yaar X linked recessive hi hona

[vale narwhal]

dominant hota to puri progeny ko hona padta affected varna jo daughter hai uske 2 daughters nhi hoti affected

[pale zodiac]

Kyunki autosomal ke hisab se isme bias bohot hain

[rugged grove]

this is by x linked dominant

[pale zodiac]

Females literally double affected hain

[pale zodiac]

Ho raha na matlab satisfy

[pale zodiac]

Vo sense bhi bana raha hai ngl

[rugged grove]

yeah so it's all of em except x linked rec

[vale narwhal]

again vahi baat ki probablity

[pale zodiac]

X linked recessive nahi ho raha?

[vale narwhal]

merko vo chiz nhi smj aari

ki agar probablity ke hisab se dekhe to ye kaise hoga

[rugged grove]

yeah cuz we cant get an affected female with an unaffected dad

[pale zodiac]

Hmm hmm

Fir to answer hi galat hai

[pale zodiac]

Dekho

Probabilities don’t work like that

Saare independent events hain

Har ek ki roughly similar si probability hai

Completely chance event

[vale narwhal]

independent hai tabhi to bolri
ki bhyi it could bhi anything
dono me hamari possiblity ideal se alag hai ye thoda mujhe hjam nhi hora

[pale zodiac]

Alag hona is very normal

You never get 50 50 na

[vale narwhal]

ik par dono time?

[pale zodiac]

Dono time matlab?

[vale narwhal]

i dont have a feeling ki bhyi isme aisa hona

[vale narwhal]

f1 and f2 both are off of bhyi ki jo usually hota

[pale zodiac]

That is completely normal yes

That too because dono independent hain

Jo bhi possible combinations honge

Roughly sabki same si probability hai

Jyada difference nahi hai

Isiliye pedigree me hume ideal ki bajaye koi or dikhne ka chance jyada hai

Just because hamara sample size chhota hai

[vale narwhal]

par yaha kaha same hai

yaha to dekho na

[pale zodiac]

Combinations ki baat kar raha bua ji

Not particular individual

[vale narwhal]

acha ruko mai combination ke hisab apko karke bhejri

[pale zodiac]

Hua ji?

😃

[vale narwhal]

bua ji se nhi hua ji
raat ko dekhungi abhi lec hai

[pale zodiac]

Bua ji DP dhoondhne gayi thi 🗣️
(Sorry not ruining the thread aage last bas)

[rapid crater]

To be closed when bot is fixed

[rapid crater]

+solved @pale zodiac @rugged grove