As you may know, South America has Alpacas and Llamas, which is represented by the wool RGO. Meanwhile, Mesoamerica at game start doesn't have a single wool RGO (to represent a lack of wooly livestock).
I suggest to add a "Native Exchange" in the spirit of the Columbian exchange, where if the player manages to contact Andean natives, they can spawn wool RGO's in the mesoamerican region before the actual Columbian exchange happens.
Edit: I've also noticed that South America doesn't have Tobacco at the start unlike Mesoamerica, so that could be given to the other side if the "event" in my suggestion occurs.
Edit2: There's way more goods to exchange than that (Potatoes, Alum, ETC), giving even more reason to add such an event.