I’ve won 3/4 runs. Found flushing is the easiest.
Just go full “flush” build.
#keep buying planets and hope for the flush level up planet. Buy any joker that assists flushes. Thats it. If your super rich try to convert your cards to one suit with tarot cards and junk.
If you don’t hit a boss ability that ruins flushes or your focused suit you win on first difficulty easy. No big brain strat required. Only thought is focus planet purchasing