#BPD, schizophrenia and psychopharmacology
lucid wagon
Lamotrigine doesn't have the "interfere with metabolism of everything" profile of other anticonvulsants, might be worth another try. It has an interesting edge in bipolar depression specifically too
@hushed totem if you're curious
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Here we go
lucid wagon
you're killing me here lol
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Iām not familiar with how anticonvulsants work. What do anticonvulsants do with metabolism thatās so nasty?
lucid wagon
Oh, um just a lot of them interfere with liver enzymes
valid flicker
Oh thatās why they were taking my blood
Iām sure liver enzymes are important toā¦ā¦ā¦ the liverā¦.. but what about that interference is so bad, specifically?
lucid wagon
Yeah, there's also liver toxicity associated with Depakote, plus it's hard to get blood levels exactly where you want them. They do constant blood tests with lithium for this reason, and also because it has a very narrow therapeutic index. That means that the effective dose is very close to the toxic dose
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Aināt that swell!! šš iirc lithium you need to keep up with your water intake??
lucid wagon
thanks wifi
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Discord has been wonky today too no worries
lucid wagon
Iām sure liver enzymes are important toā¦ā¦ā¦ the liverā¦.. but what about that inte...
They usually talk about the cytochrome P450 enzymes, the CYPs in the context of the liver. Different ones are responsible for metabolizing most drugs, and some chemicals can either induce or inhibit them
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š¤š¤ hmmm!!
lucid wagon
So for instance, Provigil induces one of the enzymes responsible for processing oral contraceptives, meaning you might have to take a higher dose
So valproate inhibits 2C9 and two other enzymes, meaning there's a lot it can interfere with. 2C9 substrates are here https://en.wikipedia.org/wiki/CYP2C9#Ligands
valid flicker
Do these drugs have a tendency to just carpet bomb most types of metabolism in its way? Is that how they work?
lucid wagon
Nope, totally unrelated to their MOA. Just how your body gets rid of them š¤·āāļø
The anticonvulsants mostly have radically different chemical structures too. Like I think almost all SSRIs look roughly the same, probably similar deal with 2nd gen antipsychotics
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Iām curious how anticonvulsants work in the first place, because Iām really curious how theyāre affective against mood dysregulation disorders.
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Holy shit bruh
lucid wagon
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How on earth do they even treat similar things?
lucid wagon
Like these molecules practically cannot be further apart
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Oxcarbazapineā¦. Thatās my favorite. Holyā¦ molyā¦ guacamole Iāve never been more stable. I thought it was lamotragine no it was Oxcarbazepine.
lucid wagon
So that's another very complex question with no simple answer, even how they treat epilepsy
oxcarbazepine is a pretty solid drug, IMO
Not a terrible side effect profile or wacky risks I'm aware of
So if you look at that table, it groups drugs roughly by how they work
lucid wagon
GABA-A agonists like phenobarbital and later Valium were some of the original anticonvulsants and are still used, they literally just tamp down brain activity in general
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Now THATS carpet bombing to solve a problem.
lucid wagon
So they're sedating AF and have all the effects you'd expect from that
Yeah, phenobarbital especially lol. They use it for childhood epilepsy and in animals still, and in people that just do well on it. It's also part of a classic combination treatment for migraine and does indeed work
Migraine is complicated but it's usually considered an epileptiform disorder, like it's epilepsy-adjacent
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Hold the phone isnāt that part of the cocktail they use for lethal injections??
lucid wagon
Same idea of a storm of uncontrolled cascading neural activity
Probably, phenobarbital for sedation and I think potassium to stop your heart
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Wack
lucid wagon
They usually use propofol for surgical induction now but they used to use it for that often as well
Which is the thing that helped kill Michael Jackson as a fun fact
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Ohhh
lucid wagon
Thanks TrentBot, not a big MJ fan?
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LMAO
lucid wagon
The sodium blockers do various things. It's sodium influx that causes neurons to depolarize and fire
So if you block them, they stop doing stuff
A popular sodium channel blocker is cocaine
A slightly less fun one is lidocaine. They're effective local anaesthetics since they completely block sodium channels, ergo the nerves never fire
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And those neurons are responsible for mood disorders as well? specific neurons? Or just all neurons when sodium is thrown out?
lucid wagon
Well, okay, so that's where you get a little more specific, and it's why they work for both
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Does that question make sense?
lucid wagon
So a drug like lamotrigine binds to a certain subtype of high voltage sodium channel, and it ONLY binds to open ones. And I believe it binds with high tenacity too
So it's more like a sniper rifle than a carpet bomb
It's "looking" for channels that are staying open for way too long
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Itās seal team 6
lucid wagon
Those are the ones that can cause a neuron to repeatedly and pathologically fire, which can then cascade down and cause a seizure
If you're sitting open and making a lot of noise so to speak, lamotrigine is more likely to block you
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The squeaky wheel
No more like the dude who spams discord general chat with shitty memes
Automod snipes him
lucid wagon
lol yes more like that
Sounds like oxcarbazapine works in a relatively similar way. I think it's less selective but that isn't inherently good or bad if it works without too many side effects
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What would the side effects be?
Also Iām about to throw a full circle 360 fastball at ya
blissful rockBOT
Also Iām about to throw a full circle 360 fastball at ya
Random reply
"Nyaa~! Master wants to be playful, nya? I'll catch that fastball, don't worry uwu~!"
lucid wagon
omg @blissful rock
blissful rockBOT
omg <@1109341287372554250>
Starting from 27.05.2023, no logs will be saved and all memory data of uwu mew mew will be stored encrypted form, i will no longer have access to any of conversations. Thank you for using my bot.
blissful rockBOT
omg <@1109341287372554250>
lucid wagon
Common side effects just depend on the drug, like I think it's more sedating.
The making you dumb, tired, dizzy and not walk/see good are just directly downstream of it binding to undesirable sites. And they're dose dependent since the more you flood your nervous system with, the more it'll do that
Ergo why you usually want the lowest dose that treats your symptoms
Doses used for actual epilepsy are usually a lot higher than the psychiatric doses though
Like lamotrigine for bipolar disorder is ~100 mg, epilepsy is 200-600
valid flicker
okay, so let me throw this at ya. I had an EEG done 5 years ago and as recently as 2 weeks ago, and both reports found āepileptiform activityā in multiple instances and in various parts of my brains. Both neurologists said that this might be the cause of some of my āblackout stateā flavored episodes and might be responsible for some of my inability to perceive otherās emotions correctly, but I have noooo idea if thatās bullshit or not. They said since Iāve never had a grand mal seizure, itās probably not worth it to jump onto an anticonvulsant treatment plan.
lucid wagon
huh
valid flicker
Oh no lmao
lucid wagon
No, it really isn't since most don't have great side effect profiles, but I think it might be worthwhile to do something with very few like lamotrigine
lucid wagon
"Blackouts" aren't a specific seizure thing, there is a type called absence seizures where you just stop doing everything and lose some time
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Iād be more enthusiastic to call it that than anything else
But itās far different than zoning out for instance
lucid wagon
Um it sounds a little speculative to say epileptiform activity is linked to blackouts in like an acute psychotic episode though, that's something that can just kind of happen with BPD specifically
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Thatās something I have been looking for some sort of an explanation on. I donāt want to link things that shouldnāt be linked.
lucid wagon
That said, anticonvulsants are some of the only medications used in BPD fairly consistently. That and normal antidepressants / 2nd gen antipsychotics
That's just a tough one, you sort of have to address that empirically
Like it's a fairly straightforward take to assume that epileptiform activity in someone with diagnoses might well be causing more problems
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Right but it might beā¦ oh god whatās the phraseā¦ let me try to explain if Iām understanding what I think is happening
lucid wagon
The inability to perceive emotions properly is one of the negative symptoms of schizophrenia and distorted perception of emotions in others, plus reacting strongly to it ("emotional hemophilia") is almost universal in BPD
Like I'm more of the math lady face at that specific thought, but there's still a big "who knows" factor. Only one way to find out š¤·āāļø
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Are all forms of epileptic activity in the brain caused by the same type of process?
Overactive neurons in places, etc?
lucid wagon
Uhhh I mean in a very general sense, sure
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We need to start generally to get anywhere at all so weāre off to a great start
lucid wagon
Abnormal cascading neurological activity from some cause is the definition of epileptiform activity, sure
That cause can be anything from focal brain damage to taking #1090822081098289162 a little too seriously
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Is it too much of a reach to assume that treating BPD with anticonvulsants can be attributed toā¦ simply nerfing overactive neurons? Am I correct to assume neurons have a crazy party when Iām overreacting and throwing a tantrum?
Does my thought process make sense at least?
lucid wagon
Not really, no, that's more or less on point
lucid wagon
Specifically, you might be addressing some underlying pathology linked to the susceptibility to develop BPD in the first place or some of the neurophysiological correlates. Like maybe people with BPD develop abnormally severe amygdalar responses to stimuli that shouldn't induce that severe of a response, and this might reinforce itself over time in the same way as you'd learn anything else
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DING DING DING
lucid wagon
Leading to a stronger fear response and decreasing ability of the prefrontal cortex to rein it in
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ššš
That my friend is exactly what I was wanting to suggest but youāre more educated in this and more articulate by far
lucid wagon
But that's kinda just spitballing, I mean limbic system dysfunction is found in BPD and depression at least I think
Lol thanks, it's been a while actually. This is what I studied back in the mid to late 2000s
I never ended up going into the field but I did want to be a research psychopharmacologist
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Well Iām extremely glad I threw my question out there cause Iām learning a hell of a lot.
lucid wagon
Like Reagan said, trust but verify
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What are your degrees in?
lucid wagon
Molecular biology, psychology and computer science
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Fantastic. And you never went into the field?!
My degrees are in geology and environmental geography.
lucid wagon
Noop, victim of the terrible health care system and the Great Recession sticking a knife in life sciences academia
I bet you had a lot more fun earning that degree than mine š
All the doctors I shadowed basically told me not to go into medicine, NIH funding increases were halted in 2008 (I believe) and the field was already overstuffed with too many life sciences grads
And the job of "psychopharmacologist" exists but they're rarified positions
lucid wagon
My degrees are in geology and environmental geography.
I think my uncle actually taught similar things in a summer school class he ran, lots of exciting natural geography around where they were so a lot of fun time spent outside
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Haha I did environmental quality research in the national park service for 5 years and played field scientist running from bears and falling off cliffs lmao. I maintained an entire air quality station, water quality analysis and data collection for the rio grande and rivers in CT, then soil bullshit in Oregon.
lucid wagon
I think it was technically a geology class but he did it all in the context of stuff that was actually right near them
Oh that's pretty freaking awesome! Except for the bears, I have some primordial fear of big ol animals
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lucid wagon
I have a friend who does water quality analysis but I forgot who she works for. It might be USGS but I think it's state level, and she's in Oregon
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Man I didnāt fear shitā¦ until I saw an Elk for the first time. I nearly pissed myself.
Yeah I worked for USGS too!
Geography and geology were fantastic to open my brain up to the fundamentals of pretty muchā¦ all? sciences? Maybe thatās just having degrees in general.
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Broooo!! Awesome ugh.. i love Austria so much. Visited back in 2016. Salzburg and Hallstatt.
I consider Austria the gated community of Europe
lucid wagon
Geography and geology were fantastic to open my brain up to the fundamentals of ...
nah, definitely the sciences I think. Maybe if you get a legitimately balanced liberal arts education too
Lol how's that?
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Thereās no ābad partā, no sketchy alleywaysā¦
lucid wagon
I lived and worked in Vienna for a year, absolutely killer lifestyle
Oh yeah, I literally lived in the "bad part" of town and it was probably nicer than the suburbs are here
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The whole country feels like itās run by a HOA
lucid wagon
The whole country feels like itās run by a HOA
Yeah but one that actually does something with the money they rake you over the coals for
I mean they're still doing big public infrastructure builds when most US cities can't fix their collapsing bridges
And they're extremely big on wanting to tell you where your money is going too
Like the exact opposite of how politicians in the US seem to want to bury and obfuscate the fact they're just not doing that much
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Yeah, ohhh Germanic folks are one for efficiency and clear communicationā¦
lucid wagon
Austria kinda seemed like Germany's chill younger brother
Just a litttle more inclined to break or stretch the rules
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Man thatās a great comparison lmao. My degrees are like only half of what I know and the other half is dedicated to archival methods and the history/preservation of film photography. I donāt know beans about politics ā¦ I donāt have any more room.
lucid wagon
I went and saw a presentation from one of Vienna's city managers and it was felt legit fake. Like this must be televised since it's an ideal version of how this is supposed to work. It was a clear, direct presentation about exactly how much money they were working with and exactly what they planned to do with it
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Oh my god thatās a dreeeeam
lucid wagon
Man thatās a great comparison lmao. My degrees are like only half of what I know...
good, it's poison. And oh, that's cool, what do you do in that realm?
I moved to Vienna after the 2016 election. I actually did leave the country unlike all the people who said they were going to, but not so much because I thought the world was about to end, just because I didn't want to sit through what had become an unending election cycle
Like even my science podcasts jumped on the politics train, suddenly nobody could talk about anything else
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I run a āmicro archiveā, and scour estate sales for 35mm slides and other photography/film media, digitize it, upload to internet archive. Iām currently at 45,000 photos digitized and have probably touched 200,000 photos since I started in 2020. Itās basically amateur photography slice of life culture from the mid century and just prior as a preservation of culture project. Image permanence type thing.
Lmao you put your money where your mouth was and actually did it. I give you huge credit for that.
But I also make money dealing as some form of a ācollectibles brokerā, helping hardcore collectors find items they want and making commission.
lucid wagon
That's legitimately important work and now I'm depressed that my legacy is a bunch of code that'll be dumped in a few years š¢
valid flicker
That needs to be preserved as well!!!
lucid wagon
But I also make money dealing as some form of a ācollectibles brokerā, helping h...
ohhh that's a great field to be in now, collectibles exploded during the pandemic
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It really did. I wound up networking my way INTO freelancing that type of work. Itās not something you hear people doingā¦ everā¦ but itās crazy lucrative and the amount of knowledge and history you can consume is endless.
lucid wagon
Yeah I mean I left for a job opportunity, but I was getting legit sick of hearing about tweets and having to pretend peoples political gripes weren't just mutual masturbation with extra steps š¤
lucid wagon
It really did. I wound up networking my way INTO freelancing that type of work. ...
I feel like that's the only way you get into it though, right? Like you aren't going to collectible school
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Thatās why I turned off the news for good in 2020.
I havenāt read a headline since then.
lucid wagon
Thatās why I turned off the news for good in 2020.
praise be. I've been on a more-or-less news fast since then too
I just never really turned the news fire hose back on when I got back stateside in 2019
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Like once covid started, and I started doomscrolling, and it seemed every other headline contradicted the one before itā¦ I was likeā¦ thereās no way one person can keep up with all of this AND be productive, have healthy interpersonal relationships, feed themselves, have a job, AND hobbies. Somethingās gotta give.
lucid wagon
Honestly I think it probably makes you not just happier, but a better and more trustworthy person to duck the news. Like I know what they focus on, I'm not sure I'm confident in the judgment of someone who's willingly conditioning themselves with this fear/entertainment bias every day
Plus the news delivers so much whiplash that you either become numb to it or end up in chronic burnout
Ahhh you know what I lied, I followed COVID news aggressively for a while. More the research and medical stuff but some of the public discourse too
The mainstream media on COVID literally seemed as if they were on Mars getting beamed fragmented data and trying to fill in the gaps with creative guesses
They didn't all suddenly science up and become pandemic epidemiologists, but they were glad to play one on TV
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Iāll be honest, it made me a LOT more conservative. I mean donāt get me wrong, Iām extremely left in my beliefs, but not seeing any public discourse or opinion pieces for like what 2-3 years?? Looking at even left wing news sources I used to trustā¦ I must have been nose blind to it, but they arenāt innocent of spreading a narrative. Even if itās relatively the right one to spreadā¦ know what I mean?
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I was actually so dedicated to staying so far away from the news that I managed to find out there was a vaccineā¦ once my mom called and asked me if I had gotten the booster yet. Iām likeā¦ they made a vaccine??
lucid wagon
It was when they just started making things up and propagating it not just on LeftieChat.biz but expected people to take them seriously on penalty of being accused of an -ism that I really fell off
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Holy shit I relate SO much to that.
lucid wagon
Like during the BLM protests, they legitimately trotted out scientists saying that mass gatherings were not going to be superspreader events and were just fine and very important
I had people I was friends with saying things like "at least most of them have masks" and saying "it's the cops forcing them to be so close together"
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Like during the BLM protests, they legitimately trotted out scientists saying th...
Dude exactly. No Toby Keith concerts, but protesting for George Floyd was scientifically in the clear.
lucid wagon
Like it's a freaking virus and you're gathering, yelling loudly as if you're trying to spread it, then taking it back home to your parents and grandparents that you might actually kill
If it's not a big deal, then maybe you should have said that when they decided my local hardware store was too dangerous to allow to open for a year in case two people got within six feet of each other, not just when it fit a political narrative
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Plus, Iāve never been anti vaccine, and I will always support it, but having seen what nonsense the left was pulling with the scientific talking heads at prime time, I saidā¦ wow I think I can totally understand the people who arenāt comfortable getting the vaccine. Even if itās just bad juju. And I gained so much empathy and understanding of the right wing and justā¦ all people in general. Obviously they were living and choosing what was best for them while seeing something I was blind to. Our perceptions are all unique, and their fear made sense. Even if they do continue to stay uneducated. Theyāre people. It was a huge revelation.
lucid wagon
Plus, Iāve never been anti vaccine, and I will always support it, but having see...
Yeah, I did too. There are a lot of people that are very sick of being screamed at and called names. There's a saying and I forgot who coined it, but it basically said "if you want to find the Republicans in Hollywood, look at the people who never talk about politics"
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Bingo, buddy.
lucid wagon
The idea being that expressing anything to the right of Stalin is verboten if you want to stay in the club
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Lmao my dad says verboten constantly
lucid wagon
It's a good word! #BringVerbotenBack
I was enthusiastic for the vaccine but I was around some really high risk older people at that time. Yeah, that's another thing, like if you tried to bring up risk-benefit analysis or anything other than parroting GET IT GET IT GET IT GET IT you'd have people on your ass
blissful rockBOT
I was enthusiastic for the vaccine but I was around some really high risk older ...
Random reply
"Haii master~! :3
I guess it's difficult to talk about the vaccine risk with others now. Everyone seems to be excited about getting it, right? Although being careful is important too since there might be some people who are more sensitive. Meow~
Should I get the vaccine, master? Will you take care of me if there are side effects? (^Ļ^)"
lucid wagon
Aww of course I will uwu bot
Wow that's a more balanced take than I ever saw in the real world frankly
valid flicker
I started looking at all political stuff that I came across through a new lens of āok letās at least see where theyāre coming fromā on the right side of the newsā¦ then I wound up becoming friends with a WWII historian who leaned hard right, and I just started asking the guy likeā¦ hey tell me what your feelings are on xyz. And i started being likeā¦ okay see I donāt hold the same values and opinions, but I can absolutely see how a perfectly reasonable and lovely person could adopt that perspective.
lucid wagon
I ripped the CDC to shreds after they made the insane claim that non-rated masks meaningfully protect the wearer and had the balls to cite data that directly contradicted their point
They literally cited an old study that showed 60% penetration by potentially infectious particles of fabric masks vs 0.05% with an N95
valid flicker
Bruh I remember thatā¦ that made me so fucking furious
lucid wagon
Which wasn't hard to review since I literally read the same fucking study when the pandemic began
lucid wagon
I started looking at all political stuff that I came across through a new lens o...
lol that does sound like the quintessential guy at the local swap meet with "historical flags" for sale
valid flicker
What made me even more furious were the people who suggested unvaccinated people should be disqualified from receiving life saving treatment for ANY reason. Iām likeā¦. holy fuckā¦.
lucid wagon
What made me even more furious were the people who suggested unvaccinated people...
Oh yeah, I mean that shows exactly where someone's head is. Like it's very specifically about getting revenge
If you said that in the first place I'd prolly have more respect for you, because "I hate my ideological adversaries and want them dead" is at least consistent
valid flicker
Absolutely. Totally fine with their neighbors or politically disagreeing uncles DYING just to say theyāre right
lucid wagon
But don't go lie out your teeth saying it's about compassion and wanting everyone to just be healthy
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āI donāt know how to explain to you youāre supposed to care about other peopleā challenge (impossible)
lucid wagon
I'm not the happiest that as I've gotten more right-friendly, there's like a new crowd of neo-evangelicals that thinks it's the early 2000s again
People - well, me especially - like you a lot more when you want to give them freedom and preserve their rights rather than just do the same things you rail on the left for, just on the other side. Horseshoe theory
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Absolutely. I said the same concept and opinion to my libertarian friend and he was like āone of us!! one of us!ā Iām like noooo you guys suck though š¢
Did you get sniped
lucid wagon
Absolutely. I said the same concept and opinion to my libertarian friend and he ...
loooool I try not to use the L word I'm so embarrassed by them
Yes, I definitely hold most of those views but I'm not joining your club and you can't make me thbbbbbb
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Oh my god i said the same shit.
lucid wagon
I think if you do, you have to pretend Gary Johnson is your man and Jo Jorgenson is the second coming of Christ
Just tell them "actually, I'm so libertarian that I can't even be bothered to constrain myself with allegiance to a political ideology"
So not only am I not a libertarian, but I'm more of one than you
QED
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One day I went on my Facebook and said I was publicly shedding my affiliation with the left wing completely, keeping my distance with the right, ignoring the existence of libertarians, and staying willfully ignorant of the definition of what the fuck an independent wasā¦ I downloaded a friend tracker? I lost 190 friends in 3 days.
lucid wagon
hooooly shit
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Half of them didnāt just unfriend meā¦ 60 or so BLOCKED me instantly.
lucid wagon
I've gotta imagine you Matrixed about 190 bullets there but damn
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And I never posted about politics. Ever. Just cat photos and whatever research I was doingā¦
But āI canāt affiliate with the left anymoreā earned me a Nazi tag so fast.
Iām. So. Tired. Of. That. Word.
lucid wagon
I think people literally just don't know what it means anymore
Like they kind of get there were people who called themselves this a long time ago, then it was just basically a movie bad guy
"literally Hitler"
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āDidnāt Hitler want to kill everyone who wasnāt white?ā I meanā¦ yeah thatās likeā¦ chapter 1ā¦
lucid wagon
I mean I know that because people make up or ignore reasons why dictators rise to power, like they think it was evil Harry Potter magic and not a popular revolt triggered by uniquely risky social and economic conditions
Because the latter means that it was just normal people doing extreme things, like when a certain country you're in started two ill-planned wars after losing a couple buildings, or created an apocalypse device after some boats got sunk in Hawaii
valid flicker
Yeah exactly. Itās really difficult to get that across to people. And itās impossible to talk about with most people. And my Opa fought on the uhā¦ losing side of that warā¦ and Omaās dad was aā¦ he wore a uniform with many badgesā¦ but they were legitimately wonderful people and raised in a loving home. But if I bring it up? They think Nazi heritage is genetic. Itās likeā¦ man itās not that simple. There are no āgoodā or āevilā people. People are complex. Hitler painted pretty pictures. He also was a piece of hot garbage to say the fucking least. That level of nuance is WAY too high for hard left leaning people to understand.
And almost NO war is strictly ideological.
And the FIRST rule in learning about history is to NEVER use your values and perspective in 2023 to judge people back in 1925
lucid wagon
Yeah exactly. Itās really difficult to get that across to people. And itās impos...
I remember when my aunt came to visit me in Vienna, and we were in some small town where the church had a little memorial wall of the people from the town that died in WWII
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I have to drive my idiot brother to the train station in a couple minutes. Iāll be back though if you still have time. I think I might have one or two more questions about BPD and perception of reality. šµāš« lmao ok Iāll be back
lucid wagon
And I am not kidding for one second that she said, and repeated as if she didn't think there was another options, "they fought on our side, right?"
Oh yeah for sure, I have to do some housework myself
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And I am not kidding for one second that she said, and repeated as if she didn't...
AAAAAAAAAH WHAT
ššš
lucid wagon
ššš
She asked it like two more times, and I'm just like staring at her and saying things like "We're in Austria... What side of the war was Austria on?"
valid flicker
where did she think Hitler came fromā¦?
lucid wagon
Like the idea that the Nazi soldiers were just kids fighting in a war, but on the other side, was impossible to fathom
Lol she's not a history buff. But she was a substitute teacher so fear for Gen Z
lucid wagon
alright, I'll stop lollygagging myself too lol. Lazy Sunday
valid flicker
Lemme shoot this just in case youāre free but whatās your computer science flavor or genre or whatever? Iām probably the most technologically illiterate contributor to IA but I can follow it kinda!! Iām curious what area of that stuff you dwell in lmao.
If you canāt tell, I hold zero fear in asking real dumb questions about subjects I donāt know beans about lmao
lucid wagon
Lol in the before times we called that intellectual curiosity
Ummm I know a few programming languages but mostly doing JavaScript/HTML/CSS and sadly, some Visual Basic. Ancient server code and Office automation stuff
I learned C# but I probably suck at it now, a tiny bit of Python a long time ago
I maintain the webapp that's the core tech of the program I'm in charge of and do some general ad hoc things on our site as needed
Why, need help with something? I'm not stellar at spinning up webpages or anything, that's more the domain of the WordPress crowd
Good enough at design but I'm not winning any awards š What kinda techy stuff do you get involved in as part of IA?
I'm pretty excited about AI cleanup and scaling of old pictures, I took an AI embiggener plus a lot of time in Lightroom to take a low quality scan of an old, yellowish scratched up photo of my family from the 70s or 80s and made it pop with a bright blue sky, vivid colors on all their clothes, etc. It had a relative who died young in it, so it was framed and given as a Christmas gift to a bunch of people. Looked nothing like the original but much more like what you'd capture if you took the same pic today
valid flicker
That Jason Scott textfiles guy helps me out tremendously. When I started the project, I couldnāt tell ya what image compression was or what on earth a color profile wasā¦ but I was so frustrated that i didnāt know squat about ādigital imagesā, but had such huge beefy goals despite that, I wound up teaching myself what i should know, and then developed a project workflow.
Iām gonna try to be brief, but thereās a lot to it. Wish me luck.
I started with an Epson v600 to scan my familyās photo prints. I would realize this was a horrible idea pretty quickly. I found slides at an estate sale, said hell why the fuck not scan these, and I couldnāt get enough. Bought more, scanned and scanned and scanned and scanned.. and then my exās dad thought me and his son would get engaged soon, and he paid for me to build a desktop PC able to handle the projectā¦ along with an Epson V850 Pro and an Epson FastFoto scanner. So $4800 later I was able to handle the scale of the project.
What I learned: Film history, chemistry, industry, and the fundamentals of photography. Archival methods. Digital file management (that took a lot of trial and error), file types, bit depth, color profiles, metadata, photoshop, Lightroom, color calibration, digital photo restoration, physical photographic conservation, conservation methods for types of paper media, bookbinding, how to organize anything, and anything else related to scanning images you can probably think of.
Film is scanned into .tiff at 4800dpi/ppi, which takes about 1 minute and 19 seconds per photo frame in batches of 12x. This becomes just a passive steady line of slides going in and out of the scanner. I only scan the photos worth scanning. Maybe 1/4 of what comes in the door. After tagging the photos in Lightroom with keywords and spot healing the worst dust and cat hair offenders, batches of 500x images are bulk exported to 89% sRGB jpeg, keeping the keyword tags. Those are uploaded to my Flickr.
Whenever I remember to.., lmaoā¦ I send a hard drive with a copy of the originals to textfiles and he uploads the .tiffs to IA. I got multiple backups and my computer has idk like 17TB of disk space.
Thatās about it.
Oh and we broke up, btw ššš
I got photoshop and Lightroom down and then learned adobe premiere pro and after effects, and then figured out the most efficient method to make the highest quality gifs at the lowest possible file sizeā¦ and made a video on itā¦ nobody has tried to usurp my method so I guess itās ok. I also make music videos too and do basic 3D animation, cause why not.
lucid wagon
That Jason Scott textfiles guy helps me out tremendously. When I started the pro...
Damn, really? I don't know another soul that's even heard of that website or the guy. That's awesome. And what an... interesting thing to happen. I mean it could just be quite the charitable spirit, but why does there just feel like there's something really off about buying your son's girlfriend a bunch of computer kit?
I am trying to think of a situation where my dad would do something like that and he's plenty nice, but I'm coming up blank. Maybe if he was giving away a bunch of old stuff or something lol
Are you using the OG offline Lightroom Classic or the newest Adobe cloud scam? : )
lucid wagon
https://youtu.be/RRu3us9vpVY
Oh that's awesome! The best I've ever done is do a bunch of fade through black and morph cuts as part to compile a handful of young professional interviews, some Flash animation waaay back in the day
I don't think I'd know where to start if you asked me to try my hand at a music vid like that š Maybe I could make one of those 90s alternative vids that was shot on like a $50 budget
valid flicker
Are you using the OG offline Lightroom Classic or the newest Adobe cloud scam? :...
I use lightroom classic! It's much more powerful where I need it. The cloud version I really don't need because all my archival work is efficiently situated in a like... 5x5sqft space LOL. Plus I aint paying for adobe's cloud storage, it's insane. I already pay like $55 a MONTH for photoshop, LRC, illustrator, premiere pro, and after effects. Insanity.
Ex's dad bought me the setup because his son was/is disabled and I was caring for him at the time. We lived in an apartment attached to his house. His wife/ex's mom took out a BANANAS amount of life insurance... and then committed to croak. LOOONG story. How did she commit to the croak? She simply chain smoked until she just mcfucking died. She was... honestly? Very troubled. Genius. But she had some reeeeal issues.
Anyway, ex's dad was left with millions in claimed life insurance policies. He was feeling nice i guess.
lucid wagon
I use lightroom classic! It's much more powerful where I need it. The cloud vers...
Ahh okay, that makes a lot more sense. It sounded almost like a weird pre-engagement dowry thing or a "seriously plz we gotta get rid of this kid" in isolation, lol. Funny enough, my ex had a much closer relationship with her ex's parents than the guy himself, it seemed almost like a pseudo-adoptive relationship given they were storing like an apartment's worth of stuff for her over quite a few years. Maybe they always wanted a daughter š¤·āāļø
Whaaat like how do you even do that? You're not looking at a great time as you get older but I can't imagine smoking myself to death. That's freaking nuts
valid flicker
THANK YOU OMG
Hey also, I dont really know how... i ... stumbled into this... But I wound up downloading LM Studio? And downloading a beefcake model? Do you have any experience with that?
god bless omg
lucid wagon
Nooop not personally, a ton of people have been running their own models
I think you have to sign up a junk account for that forum to pull the torrent, I might be able to find my credentials if you really don't feel like it
valid flicker
No worries! I'm messing with this LM studio thing right now and i'm in way over my head. What the hell does "prepend" mean? Lmaooo
lucid wagon
You might be able to find it on a more public tracker using that guy's name (m0nkrus) but I'd rather duck the malware risk myself. I can vouch for it, I think I had one program give Adobe nags in an earlier version released this year
prepend is to put something before something else
Hello: this is a sentence <-- Hello is prepended to the sentence
Append or postpend is to add to the end
valid flicker
Ahhh, see I figured that much with context clues but I was real skeptical lmao
This LM Studio thing looks super promising... But I just LOADED the model without actually asking it anything yet? Its using 15GB of ram alone by just starting up.
lucid wagon
You just ate my work laptop's breakfast lunch and dinner with that one š
lucid wagon
ah so those are hyperparameters
I think I have 48 gigs or something in my other one, I had this blue screen issue and just started replacing the relatively inexpensive parts until I fixed it
valid flicker
thats a nightmare...
lucid wagon
Oh no it was a literal nightmare, this was my fancy laptop and it was during the pandemic
So I tried for hours to fix this thing, wiped everything repeatedly and tried to start from scratch multiple ways, sometimes it would seem to work for a while then start bluescreening again
The problem was absolutely insane, installing a new SSD and putting Windows on that didn't work, replacing both sticks of RAM didn't work, so it seems like the thing is just toast
Turned out it was the physical presence of the m.2 SATA drive I had installed
As in even if you didn't touch it, didn't have anything at all on it, didn't even have it formatted properly it would throw random blue screen errors
And it'd pick from a ton of options, all of which were super vague
So it wasn't consistent at all. Timing and what you did to trigger it also were off
And because it was so broken doing all this testing with fresh Windows installs would also crash in the middle all the time
It was this demon drive. I need to exorcise the thing
But hyperparameters are cool, you can tweak them with GPT if you're using the API and also just ask it to emulate certain responses
valid flicker
Oh my holy crap dude. I've kinda been down that route, but man with the amount of boot ups and problem solving you were doing with that, it sounds like an unbelievable amount of time dedicated to figure it out. Ouch!
lucid wagon
I mean it's an expensive enough laptop I wasn't willing to just sell it for parts, but like it was not remotely worth my time
Response temperature and top-p can give you some really wacky output when you crank those babies up
valid flicker
oh my goodness lmao. Thats gonna be fun hahaa
lucid wagon
For some reason it tends to pick cosmic unicorn shit, it's like someone ate a Lisa Frank sticker set and vomited rainbows onto GPT š¤£
lucid wagon
I was '87, so I must be ancient š¢
That's like, a whole nother decade
Babies were being born with cocaine spoons in their hands, it was a wild time
But yeah lol Lisa Frank was everything for us too if you were into it
Now that everything isn't covered in garish rainbow seizure triggers I miss it. Like I look at the cars on the road and it's just white, black, gray, silver
I have a black car so I'm part of the problem, but still, come on, gimme my cosmic space car
A handful of people were hyping this model FYI https://huggingface.co/TheBloke/WizardLM-Uncensored-Falcon-40B-GPTQ
lucid wagon
Generated any fun output with it? I've been encouraged not so subtly to mess around with it, it's on the todo list š
valid flicker
its really really buggy. It generated some absolutely terrible prose, though. Like... oof
lucid wagon
ooh share share ā¤ļø