Since the latest patch (I have experimental (I have 0.23 experimental), the autosave continues to fail, as does the ability to manually save a game. It was working just fine yesterday afternoon. Then this morning, I noticed a d/l occurring, and since then autosave and manual saving is a no-go. See the screenshot I took of the error message.
I have 180Gb freespace on my drive. Everything else is working well on my PC. It is running Win11, with plenty of grunt, latest patches, etc.
I did submit a bug report via the game as well, but figured I'd send it here as well.