Depends on what you want exactly, it'd be challenging as you couldn't really use baked shadows the same way. I've done it once by making custom shader for the skybox that was synced with the sun position, which was animated, not sure yet if this is possible in Spatial. Animating lights is certainly possible so that could potentially be used to make let's say lighting flashes and such too
#Day/Night Cycle and more
agile pewter
particle effects allow for snow and rain too, one of my spaces has falling snow actually right now