I have experienced my patreon bonus randomly wearing off at least 3 times now in the span of 4-5 days. At first I didn't realize what it was because the text still says the bonus is active, but looking in the quark multipliers in stats for nerds, I found that the patreon bonus was 0.
Long story:
The patreon bonus was active, and it was proven because the quarks from exporting was increased once it activated. Then, in a period of about 10 minutes, in which I only remember exporting and later ascending, it had fallen off. Buying orbs didn't increase my quark corner at all and the export max had shrunk. I checked the quark multipliers and patreon bonus was at 0 again. No idea what caused the patreon bonus to wear off, but refreshing the browser fixed it pretty quickly. Still annoying.
Short story:
Had patreon bonus. Exported. Ascend 10 minutes later. No patreon bonus. Refreshing page and patreon bonus activates again.
If it matters, I am on chrome browser on PC.