This is something someone mentioned earlier on but I'll go ahead and start a thread on it.
These would basically be blessings that offer some sort of trade off for greater reward than a standard blessing. How they are obtained and used can be a bit different from how blessings are used but the core idea is for there to be a tradeoff.
This is a mechanic used in other rougelikes as well, such as Wizard of Legend for example. As far as the exact mechanics, and specifically which curses might exist would be up to the devs, but suggestions and general discussion could be directed here where it won't be buried in another channel.