I'm not even close to being a developer, so I'm unsure how challenging these suggestions will be to implement.
I would like to see more settings or even an adjustable value/slider for more options such as...(all being optional sandbox settings preferably for a customizable experience)
Needs(Hunger, Thirst, Sleep, Recovery) - IMO this is an underrated part of the game and is good for immersive play, but I feel it could be more demanding without taking away from the game. This would also slightly alleviate the issue where there's currently no real money sink. Having to spend to maintain your needs could serve as a small way to keep pressure on the player to complete jobs at a reasonable rate.
Rent - I've seen this suggestion multiple times and it makes sense. There is no pressure when it comes to money, and having to pay rent to not be homeless would go a long way for this. IMO, a weekly cost makes sense since daily costs may not work too well with fresh saves. Having differences in costs of rent would also give the player more decisions to make, such as deciding to stay in a low-rent apartment for lesser aesthetics, space/storage, higher risk of danger on its street, compared to the benefits a more expensive apartment would bring.
Perhaps also make it so having items such as a Fridge, Shower, TV, Phone, Storage, slightly increases your weekly costs.
Economy Settings - Currently there's a difficulty setting that only changes the damage model. A setting for Economic Difficulty would do a lot for players looking for more challenge. This goes hand in hand with my views on Needs and Rent. IMO, being able to adjust things such(preferably separately) as Job Payouts, Costs of Items/Food, Hospital Fees, and Rent would allow the player to find an experience much more suited for themselves.