The problem was always a race condition with targeting and autoattacks automove, and also a problem with the WASD switch of RMB to a different RMB that passes through windows. There are a bunch of those races particularly around held-down keys because it seems like either you're not regenerating events each tick or sometimes processing events out of order.
It wasn't related to people clicking a lot. Now I can't target with the mouse and have to use tab and it's even more glitchy than before.