Tried out the demo for the first time yesterday, and I kind of found it a bit of a headache with how everywhere all the important information is.
Like the main stuff is center screen, combat stuff is a thin-ish line on the top of the screen, virus blocks are in a corner, actions and perks are in another corner. It's not bad, but definitely not for me. I compare this to Ring of Pain where for the most part, everything is centralised, and even when you need to look at the lower part of the screen for your items, their tooltips are huge and in rather consistent positions.
I am curious about the font size though. I feel like it's just bigger in Ring of Pain.
Anyways, the demo still looks interesting and I think the gameplay is cool, so I'll probably try it again later when my eyes don't feel like they're going to explode with how much I have to move them.