Finally just a request, meta run unlocks are not in the demo as of yet but I have seen they will be. I request that if any of the upgrades add to loot pools such as a new perk that there is an option even if in a separate mode to turn them off or choose which you want active. In quite a few games I feel as if unlocking things just makes your future runs weaker by diluting the pool with bad or non-synergistic choices. My favorite of these modes is done by Deadcells, it is practically a cheat mode but treats it as a normal run if you follow some criteria such as having a minimum amount of weapons selected and not turning on some far more cheaty settings. It allows you to experiment with new builds and lets you unlock things without worry of ruining every future run till you wipe your save. Please even if you take nothing else from my feedback PLEASE add a mode or options similar to this. You could even theme it around customizing your specific virus.
On a semi-related note it would be nice to have a seeded run as an option. Something where all the same random elements line up the same way every time with that seed. Something like Balatro's seeded run option.
I just thought of this so I'll just throw it in, would be nice to have run modifiers such as all healing in infection stage are replaced with cells and stuff like that just for some challenge, verity or personalization.