2D VFX on WebGL Build Not Rendered on Chrome Mobile Browser

[sterile dew]

The VFX is prefab with a 2D material sheet used for Texture Sheet Animation field. It also uses Emission, Shape, and Render fields.

[sterile dew]

Could the shader be the problem? The effect was using Legacy Shaders/Particles/Alpha Blended.

[bitter ermine]

Seems like something worth to test
Have duplicates of the particle effect in your build with various different shaders
And for good measure include a default particle system you get by creating a new particle system gameobject which uses the default material and only a few modules

[sly nexus]

I had this issue with some particle systems before. They worked in PC builds but not in WebGL. Turns out the problem was with Custom Vertex Streams being set up wrong. I don't recall exactly what I did, but you could send a screenshot of the Render module and the material

Are you using billboards or meshes for the Render Mode?

Also have you tried changing the material to use the 'Particles/Standard Unlit' shader?