It takes a powerful round to anchor the biggest animals or the very least a sharp blade with plenty of force behind it. So I suggest these. After all, we have lions, tigers and bears to take on. This list is three powerhouses you can rely on for the biggest and meanest game we have.
First, a constant favorite, the .375 bolt action. I chose Mannlicher (full length stock) style because it's unique in all the weapons we have and can handle 4 rounds.
Next, the .416, a cannon that professional hunters rely on to stop the biggest and angriest animals that Africa can produce
Last, maybe most impressive. A compound bow with a draw weight of 100 pounds, purpose built to drive arrowheads through the thickest and toughest hides the world could offer