So when you get too many debuffs with Cursed Ulcer the game will jam and then eventually crash. Happened two times in a row now. I guess gotta play on easy mode and just stand in one spot to avoid any debuffs.
I'm not the only one and it was also tested out: https://www.reddit.com/r/hallsoftorment/comments/1ok3tou/cursed_ulcer_artifact_bug_game_crash_100/