I am trying to install 2 mods (One probe all resources and Skip mini games), and I can't get either of them to work. When I do a fresh install of the game (through Steam), I can open Mod Manager and Start Game when everything is vanilla. As soon as I apply a single mod, the game crashes during launch. I get the ME2 splash screen, and then nothing. When I go to Steam and try to launch the LE Launcher (which starts successfully), trying to start ME2 just flashes back to the launcher.
Even when going into the Manage Target menu, and restore the mod, the game will not start. I have to restore the full backup before the game launches again.
The issue is the same with either mod, so I'm leaning towards the Mod Manager or something else with the game being the problem, and not either individual mod.