TL;DR: Can I use the ZBT-2 device (or even multiple) remotely via Ser2Net running on a remote Raspberry Pi?
Today, I use HA on Docker on a Synology NAS, although I will be moving to a new home in 2026 and likely move back to a full VM (either way, HA will be virtual). It was impractical for me to add the current ZigBee controllers directly to the host, so I currently run a couple of standalone Raspberry Pis that have SONOFF ZigBee controllers attached, and the Pi OS runs Ser2Net. This allows the controller to be connected to a unique instance of ZigBee2MQTT (I need 2 ZigBee2MQTT instances with 2 remote controllers because there is significant overlap in the other locations where I run various ZigBee devices, yet I wanted them all in a single HA instance).
In the new house, I want to switch primarily to Thread + Matter. I was interested in the new ZBT-2. I know this is just a USB device, but I wanted to see if I could attach it to Home Assistant in a similar way by connecting it via Ser2Net, then have Home Assistant recognise the ZBT-2 device. Further, can I have multiple ZBT-2 devices on the same HA instance, as I do with the current ZigBee controllers? In the new house, there will still be a significant distance between my primary and secondary locations.