If you open any of the equipment wheels while moving in any direction, when the wheel closes, movement is halted. This is incredibly disruptive for the flow of gameplay, especially in brutal.
If you're backing away from an enemy and then open the wheel to quickly change weapons, you won't be able to dodge immediately after closing it and you'll instead jump in place. Even if you never stopped pressing the WASD keys.
This means even if you see the enemy buffering an attack, you won't be able to dodge it when you close the wheel; unless you actively remember you have to remove your finger from the movement keys and then press it again. Good luck with that in the 1.5 seconds you have to think. I suspect this doesn't happen on controller.
It's an otherwise awesome game and combat system, but it breaks your immersion completely when you're kicking butt and then jump in front of the enemy's face like a chump.