There are 2 unmarked NPCs that you need to talk to so that you can start the courier questline, though if you miss both opportunities to talk to them it's impossible to get the quest line. There is a side mission called People of Interest quiz that requires you to meet Driscoll, from the courier questline, and it's impossible to complete it since it's also impossible to meet Driscoll.
#People of interest quiz cannot be completed because of missed side quest
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Its not "impossible". You can do the carriers quest if you missed both npcs still.
how
@carmine fog i got the quest when i visited the bartender at fisheye. That was during my 1st playthrough. I never spoke to the carriers.
you cant speak to him after you finish the game
@carmine fog can you speak to the second carrier in the pk ship? If not, i believe the bartender gives you the quest after doing rats in the house.
both carriers are gone, the bartender doesnt have any interactions. ive completed every main mission and side mission, the only one still available on my map is the people of interest quiz, which is impossible to complete