I spent a ton of time on this, and I wasn't able to get the 2d skeleton stuff to function right. My issue was with the mesh transforms always looking bad. The tools in Unity are just better here. I made a game using them where I took hand drawn pen and ink and animated it.
That being said, what about it is throwing you off? Is it the physics part? The hooking up the bones to the bones? Setting up IKs?
#Skeleton 2D and physical bones?
ancient imp
shadow shadow
admittedly I haven't really tried everything out yet, first thing I did was give some rigid bodies some bones and it felt really messy so I looked into my options