I know many people have reported this and I'll be just adding to the pile, but I can't find a fix anywhere either.
As the title says, when I'm in the game, alt+tab into Wand, hit play and activate a mod, the game crashes.
There have been two patterns for me:
In the first one, I'm in the menu when I go into Wand and hit play, always activating god mode first. When I go back to the game, nothing happens until I click "Continue" or try to load a save, as that's the point when it crashes.
In the second pattern, I load into the game save and wait until I can move around, press Esc and then go into Wand and hit play, activating god mode first again. Going back to the game, once I try to resume, that's when it crashes.
I have the game from Steam and running it completely vanilla