I am using WeMod to load in SoTF for building as the invisibility toggle is a lot more reliable than the F1 typing it in and the toggle for the debug mode is handy. However I am currently losing hours of work on my builds because the game is crashing on a regular basis. It doesnt do this when I am playing without WeMod to this degree - I'll get an occasional freeze up and crash but its rare.
I play on multiplayer because its a server my husband and I are playing together (I host), so when he's at work and I'm off, I'll jump on to build or improve our bases.
The game also takes ages to load in when I use WeMod. When I dont, it loads up very quickly. Talking 5-10 minutes vs 1-2.