Harder Walls: With this one the only way to can break walls is with explosives, fire or Character with the giant status. Or deconstruction if that is a mechanic.
Michael Bay: everything explodes. you kill someone? They explode. two cars crash into each other? They both blow up. Object gets broken? Better hope there's nothing near it since it's going boom.
Group hatred: all "factions" (gangsters, soldiers, mobsters, etc.) Will be hostile. All other NPCs stay neutral.
Creeping Ooze.: an blob like creature is slowly destroying the world! It will spread endlessly, destroying everyone and everything in its path. How long can you last?