TL;DR Are you getting severe mouse input lag in games with wooting keyboard? Mumble default settings are incompatible. In Mumble go to settings --> shortcuts and untick "Enable Xinput".
I had this issue of very severe mouse input lag ingame after hitting a button on my wooting two keyboard sporadically since last year and I've posted here about it a few times. I had suspected my x370 amd platform of being potato for usb, but that was mistaken. I was alleviating the symptoms by running 125Hz usb update frequency for my mouse, which worked as a bandaid.
Today I figured out a root cause and a solution, so I'm reporting back with it: it's a Mumble default setting incompatibility. In Mumble go to settings --> shortcuts and untick "Enable Xinput". Doing this appears to work as a root cause solution for the input lag I was experiencing. Attached is the image of my Mumble shortcut settings.