#Is there any advantage to do solo runs vs co-op (2-4)?
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Never paid much attention to that, but a huge difference is that in coop players can revive each other, while in solo it's game over
less enemy spawns, yes but same amount of gold veins/stuff on the map (depending on the difficulty, soul enemy spawns may vary) as for exp, you lose exp if you extract with some dead players (there's a -[amount of exp] if not all players are alive at the end of the mission)
Less enemies and elites/bosses have less health
generally coop goes quicker if youre collecting everything. Aswell as getting more jokers per horseman or chest.
However solo lets you control the pace of a mission, less enemies, and being able to take all the ammo/health.
you can pause the game in solo
thats why i run solo