I hovered over the Bottle of Water in my inventory and I enabled "Enable Autodrink", I then turned it off some time later.
Now every time I load up my save game the "Enable Autodrink" has turned itself back on again.
So if I hover over a Bottle of Water now, it will read as "Disable Autodrink", but in the Option settings under "Accessibility", the check box remains unchecked, so this this should not even be possible.