Im not talking about making them do more damage and what not but i think having nuclear exchanges being much bigger and impactful would be cool. For starters having "strike packages" similar to tacticfront would make large scale nuclear wars easier. A system that encourages people to save up more money before using nukes, maybe by penalizing the first person to use nukes would also help, and encourage retaliatory strikes.
Overall anything that makes using nukes feel more impactful and apocalypse like (kinda like pre nerf MIRV).