While fooling around with tropical smoothie stacking, i rigged a space joker and a copy-paste at different points, both for convenience.
Eventually, the game started to crash when i tried to play a hand, and eventually isolated it to where using a single additional tropical smoothie crashed.
Selling the space joker fixed it, and later the game started to crash when I used code cards (which selling the copy-paste fixed), so I can only assume it's due to RNG being called with extreme odds (the odds were at double-e level by then).
I'd bet on this crash happening in vanilla, too, but good luck getting over 1000 oops all 6s in order to get any odds that high