While in "destroy" mode of the building menu to delete a roof for upgrades, the game stopped responding to any keyboard input besides WASD and mouse input other than camera movement.
I was unable to destroy built objects, unable to exit destroy mode, unable to exit build mode, and unable to exit the game. Had to force-close via taskbar.
The issue was unrelated to my PC, as pressing the windows key brought up the start menu and taskbar and allowed me to force-close the game, and all inputs worked normally everywhere besides in-game (even while Windrose was still running).
Edit: In case this info matters I'm accessing the game through a hosted dedicated server, but the server console did not display any errors in the log, or at least none I was able to interpret as an error.