When switching between control presets, any changes I've made should be preserved. For example, if I switch from MOBA-style controls to WASD + Mouse, or back again, the adjustments I've made with memory settings, advanced options, directional movement, and so on should not reset to default.
This would simply save people like me from having to reconfigure their ability casts and other settings every time they switch control presets. In my case, I enjoy both MOBA and WASD + Mouse controls, so I switch between them from time to time.