I am an incredibly lazy person. Sometimes I wish I could just play the game with one hand on the keyboard. Besides, you can play almost the entire time game with just the mouse, so why not allow the keyboard to do the same?
My suggestion is this: map the "Left" and "Right" arrow keys to select a spell in your hand in combat. The "Up" arrow key could be mapped to move from selecting cards in your hand to selecting a target (since targets are above where the card UI is). The "Down" arrow key could also be mapped to moving from selecting a target to selecting a spell in your hand again, opposite of what the "Up" arrow key would do. Finally, the "Enter" key could be mapped to confirm your selection and send it to the game server. It would be nice if "WASD" keys behaved similarly to the arrow keys as well.
Let me know your thoughts 🙂