Some Blinds appear too early/late.
The biggest example is The Serpent, which appears in ante FIVE, but is one of, if not, the easiest boss blinds. Ante 1 or 2 is good.
A reverse example is The Flint. Ante 2 feels a bit too early. 3 is good.
So here's the list of all the boss blinds which I would move up/down
Needle: 2 -> 1 im not so sure about this one
Wheel: 2 -> 1
Flint: 2 -> 3
Mouth: 2 -> 3
Plant: 4 -> 2
Serpent: 5 -> 2