Skip the first 2 blinds to get Polychrome Madness, then spam the fuck out of Standard and Celestial packs.
Seed Money and Clearance vouchers help a LOT, and an econ tag here and there couldn't hurt. Basically, just have enough money to spend on anything EXCEPT more Jokers, since that's what the aforementioned packs are for. Also, as far as I'm concerned, do NOT reroll in the shop, either. And don't skip too many non-boss blinds, since Polychrome Madness can and SHOULD be leveled as often as possible.
Still playing this seed on White Stake to get the most enjoyment out of it. Will report back with more findings as I trial-by-fire my way through this. Help is much appreciated!
Pic unrelated btw.