Hi,
I have a few hundred hours in Balatro on a very decent system (please see attached file), but no matter what I did it kept on crashing at least once an hour (with a full system freeze requiring a restart, no less). From what I hear, a lot of folks have the same issue.
What didn't help: having the latest Nvidia drivers, removing old instances of Visual C++ Redistributable, changing window resolution and mode between fullscreen, windowed, and fullscreen borderless.
What helped: Turning off V-Sync in Balatro settings. I've played about 6 hours so far without a single crash in a widescreen borderless (3840x1600).
Cheers!