I currently have two monitors on my PC, both with identical display specs (1920x1080 resolution, 60hz refresh rate), but one monitor uses HDMI and the other uses DisplayPort. When using the "Extend Displays" setting to use both monitors, Balatro will hang upon launching if it attempts to launch in fullscreen or borderless windowed. I can circumvent this by setting my displays to only show on one monitor or duplicate my displays (shown in the video by the section where only the right display is shown, which is my primary monitor), and I can mess around with the game even in windowed mode after setting it back to extend, but attempting to use fullscreen on my secondary monitor at any point causes the same hang.
I saw an older post about this that someone managed to solve by disabling something in AMD software, but I don't have an AMD processor or that software problem going on. PC specs for reference