Have 5 hand size due to early Ectoplasm pick ups, used a held immolate to kill a pack hand leaving no cards selectable. All of the tarot cards required targetable cards, which left me unable to use a card or skip the pack.
Edit: never mind on this bit, leaving it up though: Worried about a similar issue with immolate/ hanged man during runs: can't discard or play if you kill the whole hand.