I had thought that for late-game you could somehow unlock a booster pack that allows you to introduce two jokers in it and create a double-sided joker (it would be perfect for the theme of the jokers as graphically they have text for one direction and another), the mechanics would be that once per blind allows you to decide whether or not to turn the joker and decide the effect that suits you, this mechanics could be adapted to a deck or a challenge too, but I thought it would be interesting :)
I leave an image with concepts in here. Any comments, changes or additions are welcome. This is only a brief basic idea.