Had a run where after completing the small blind in the first ante, I purchased a Space Joker from the shop and then closed out of the game. When I reopened Balatro and continued the run later it began at the shop showing the Space Joker was unpurchased and I was refunded, which is normal. But when I bought it again and continued my run, the Space Joker didn't trigger once for about 20 hands until I sold it during ante 4. It's possible I was incredibly unlucky (0.75 ^ 20 = 0.3% chance?) but I think it could potentially be a bug that affects chance-related jokers if they're bought before closing the game and then repurchased.