Start a run with permanent unmovable dagger.
Maybe to go overboard it could also destroy all jokers, not just one 
Or maybe make all jokers debuffed(except dagger)
#Sacrifice
covert solstice
hallow flare
i think a similar challenge idea was already implemented by localthunk which was inspired from GLUK
in general, that suggestion is "eternal ceremonial dagger that is pinned to the left"
covert solstice
Oh cool